The thrombospondin-1/CD47 axis in kidney transplantation.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1016276

Funding Status
Closed

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Funded Activity Summary

Kidney transplantation is the preferred treatment for kidney failure. At transplantation when blood flow is restored to the organ, a massive burst of inflammatory and oxidative products ensues, a process known as “ischaemia-reperfusion injury” (IRI). This damages transplanted organs and activates the immune system, causing organ transplant rejection and loss. This project will investigate the TSP-1/CD47 axis and its manipulation in renal IRI as a focus for reducing organ injury, rejection and transplant failure.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2018

Funding Scheme: Early Career Fellowships

Funding Amount: $372,528.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Transplantation Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

immune modulation | ischaemia/reperfusion | kidney disease | kidney transplantation | nitric oxide | reactive oxygen species (ROS) | rejection | transplantation | vascular biology

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