Identifying the mechanisms by which ascorbate stimulates cellular iron uptake from transferrin.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1013810

Funding Status
Closed

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Funded Activity Summary

Vitamin C (ascorbate)-deficiency leads to anaemia and other symptoms of scurvy. Iron supplementation cannot alone correct this anaemia, with ascorbate being crucial. Almost all iron in plasma is bound to transferrin, and I have recent data showing that ascorbate stimulates transferrin-iron uptake. This research will identify how this stimulation occurs. This work has important biomedical implications for understanding iron uptake and anaemia, which affects 500 million people globally.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Early Career Fellowships

Funding Amount: $302,123.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Metabolism

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

anaemia | ascorbic acid | cancer cell biology | iron metabolism | transferrin

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