Novel antibiotics targeting bacterial secretion systems

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1013649

Funding Status
Closed

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Funded Activity Summary

Infection caused by pathogenic bacteria is a major health concern. Strains of bacteria are constantly becoming resistant to front line antibiotics, driving the need for more effective treatments. A drug target that is not currently utilized in clinical treatment is a family of molecular nano-machines embedded in the bacterial cell wall. These machines are called sectretins. The aim of this research is to fundamentally understand their molecular architecture in order to guide the design of potent and selective inhibitory drugs.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2015

Funding Scheme: Early Career Fellowships

Funding Amount: $303,357.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antibiotic resistance | antibiotics | bacterial pathogenesis | crystallography | infection control | membrane transport

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