The involvement of bone cells in the adverse side-effects associated with therapeutic glucocorticoid use

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/GNT1013295

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Long-term use of cortisone (glucocorticoids) often leads to significant health problems such as diabetes and obesity. We have convincing preliminary data suggesting these side effects are, at least in part, mediated via bone cells. Inhibiting cortisone action in these cells, in mice treated with cortisone, results in a significant reduction of the negative side effects of this drug on fuel metabolism (eg glucose and lipid levels). The current aim is to investigate how this pathway is involved in cortisone-induced obesity and diabetes.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2017

Funding Scheme: Early Career Fellowships

Funding Amount: $290,032.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

glucocorticoid-induced bone loss | glucocorticoids | hyperlipidaemia | insulin resistance | metabolic control | mouse models | osteoblast | osteocalcin

Related Links