The role of clusterin in preventing atherosclerosis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1012521

Funding Status
Closed

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Funded Activity Summary

In atherosclerosis, plaques are formed when damaged low density lipoprotein (LDL) and fibrinogen are deposited inside blood vessels. Clusterin is a protein that stabilises damaged clients in soluble complexes, thus preventing their deposition. This project will investigate the ability of clusterin to prevent the deposition of damaged LDL and fibrinogen. Elucidation of mechanisms for preventing protein deposition will identify novel therapeutic targets for the treatment of atherosclerosis.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2016

Funding Scheme: Early Career Fellowships

Funding Amount: $352,662.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

atherosclerosis | clusterin | molecular chaperones | protein folding

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