Bitopic ligands as a novel approach to G-protein-coupled receptor selectivity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1011920

Funding Status
Closed

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Funded Activity Summary

This project will focus on two important types of brain proteins that have been implicated in various symptoms associated with schizophrenia. The aim is to exploit a new paradigm of drug action that we have discovered, whereby novel compounds can be utilized to simultaneously target multiples sites on these brain proteins, in an effort to discover new mechanisms that can promote more selective signalling and, ultimately, can be used to design safer and more effective medicines.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $540,356.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Basic Pharmacology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | G protein-coupled receptors | central nervous system (CNS) diseases | dopamine receptors | drug design | drug discovery | drug efficacy | muscarinic receptors | schizophrenia and related disorders

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