The impact of the changes in levels of adhesion molecules NCAM2 and DsCAM on synapse formation and function: implications for Down syndrome

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1011478

Funding Status
Closed

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Funded Activity Summary

Down syndrome (DS) results from triplication of chromosome 21 and leads to mental retardation, molecular mechanisms of which are not understood. We found that two proteins, NCAM2 and DSCAM, encoded at chromosome 21 are highly expressed in synapses. Synapses are specialized contacts between neurons which allow neurons to process information in the brain. In this project we will test a hypothesis that changes in NCAM2 and DSCAM expression result in synapse abnormalities observed in DS.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2015

Funding Scheme: Project Grants

Funding Amount: $334,053.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Down syndrome | adhesion molecules | neurons | protein characterisation | synapse formation

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