Sulfonadyn-based dynamin I-specific inhibitors and epilepsy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1011457

Funding Status
Closed

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Funded Activity Summary

Epilepsy affects 1% of people, yet 30% do not respond to anti-epileptic drugs (AEDs). Traditional drug discovery fails to improve this situation. Our team discovered dynamin as a new target for better AED design and our lead sulphonadyns reduces seizures in animals. We will design better sulfonadyns that can ultimately be used for clinical trials by designing the drugs away from its actions outside of neurons. If successful, this will accelerate new AED development with less side-effects.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $835,291.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antiepileptic drugs | drug design | dynamin | epilepsy | medicinal chemistry | nerve terminals | neurons | synaptic transmission | synaptic vesicles

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