Influence of TCR signals from contact with self-MHC ligands on naive T cell survival

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1011388

Funding Status
Closed

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Funded Activity Summary

A diverse repertoire of naive T cells constitutes a critical part of the adaptive immune system and protects hosts from various infections and cancer. T cells are stably maintained at a constant number in the periphery by mechanisms that are not clearly understood. This proposal will shed light on how the immune system preserves a diverse na�ve T cell pool able to respond against various foreign antigens, while preventing their harmful auto-reactivity to self antigens.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $418,658.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Immunology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

T cell immunity | T cell receptor | T cells | autoimmune disease | cytokines | diabetes | homeostasis | inflammatory bowel disease (IBD) | self tolerance

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