Effects of the histone acetyltransferases MOZ and QKF on chromatin modifications

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010851

Funding Status
Closed

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Funded Activity Summary

Cancer of the blood (leukaemia) can be caused by rearrangements of the genetic material (DNA) that cause fusions between ordinarily separate proteins. Monocytic leukaemia zinc finger (MOZ) fusion proteins cause aggressive leukaemia. We have shown that MOZ associates with DNA packaged with histone proteins into chromatin, changes histones and gene activity. We will examine how MOZ and the closely related QKF protein affect the chromatin to elucidate the function of MOZ and QKF.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: Project Grants

Funding Amount: $349,576.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

basic science | cancer | chromatin | developmental biology | developmental disorders | genetic disorders | genetics | stem cell biology | transcriptional regulation

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