Understanding the Molecular Basis of Epididymal Maturation: How Does the Epididymis Modify Spermatozoa, Allowing them to Recognise the Egg ?

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010753

Funding Status
Closed

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Funded Activity Summary

Male infertility is a significant clinical problem affecting one in twenty Australian men. A common feature of this condition is the sperm’s inability to recognize the egg. Sperm gain this property as they transit an organ known as the epididymis. We have produced genetically modified mice with a specific epididymal defect that prevents sperm-egg recognition. This study will examine the structure of these defective sperm to generate new insights into the molecular basis of sperm-egg interaction.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $585,898.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Receptors and Membrane Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

male contraception | male infertility | male reproduction | membrane signalling | proteomics | quantitative | reproduction | transmembrane receptor

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