Prediction, verification, and clinical significance of splicing aberrations associated with BRCA1 and BRCA2 variants

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010719

Funding Status
Closed

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Funded Activity Summary

There are many families with sequence changes in the breast cancer genes BRCA1 and BRCA2 for which the consequences cannot be easily predicted. It is not possible to offer informative genetic counselling to these women or their at-risk family members. This study aims to refine computer prediction models that are used to predict if sequence changes disrupt the way the gene product is collated in the cell, and what amount of disruption will lead to cancer. This will improve patient management.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: Project Grants

Funding Amount: $572,995.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

BRCA1 | breast cancer | cancer genetics | cancer predisposition | genetic disorders | genetic testing | ovarian cancer

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