Cis regulatory and functional analysis of genomic loci with implication in hypothalamic obesity using the zebrafish as a model system

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010713

Funding Status
Closed

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Funded Activity Summary

Gene regulatory mutations cause changes in gene activity (expression -level, -time, -site) and therefore decide about the availability of proteins. Regulatory mutations in uncharacterized genomic loci that are related to obesity and further their effects shall be identified, with emphasis on those affecting the hypothalamic food intake control circuits. Since the energy metabolism system and the obesity candidate genes are conserved, the model system zebrafish will be used for these analyses.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $480,936.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurogenetics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

gene regulation | genetic disorders | genetic predisposition | hypothalamus | neuroendocrine differentiation | neurological diseases | obesity | transgenesis | zebrafish

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