Identification of the molecular mechanisms by which mutations in FHL1 lead to protein misfolding and skeletal muscle disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010655

Funding Status
Closed

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Funded Activity Summary

Skeletal muscle diseases result in debilitating muscle loss and may result from an error (mutation) within a gene. Mutations in FHL1 were identified as the cause of four different muscle diseases. Using purified FHL1, skeletal muscle cells and animal models we will investigate how FHL1 mutations cause muscle wasting, and loss of muscle strength.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $609,424.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

dystrophy | knockout mouse | mutation analysis | myopathy | protein aggregation | skeletal muscle | skeletal muscle wasting

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