Consequences of Waveform Composition for Epithelial Integrity and Homogeneous Ventilation during HFOV

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010575

Funding Status
Closed

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Funded Activity Summary

High-frequency oscillation (HFO) delivers up to 900 breaths/minute to newborn babies. In theory, the tiny HFO breaths decrease ventilator induced lung injury whilst efficiently delivering oxygen to and removing waste gas from the blood. However, HFO may damage the large airways due to the high gas flows. We will use mathematical models and studies in preterm lambs to assess how to optimise distribution of fresh gas to the lung while minimising any airway damage. Our findings will help doctors treat preterm babies with lung disease.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: Project Grants

Funding Amount: $409,483.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Human Biophysics

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

airway epithelium | mechanical ventilation | mechanotransduction | premature infant | respiratory distress syndrome (RDS) | respiratory physiology | shear stress

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