Testis to ovary: hormonal control of differentiation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010453

Funding Status
Closed

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Funded Activity Summary

We know very little of the genes that control development of the ovary in female fetuses; most study has focused on the formation of the testis in males. We will use a novel experimental model, a marsupial, where by hormonal treatment of developing males we can switch off testis formation and activate the ovarian pathway. These studies will potentially shed new light on the causes of reproductive diseases including ovarian cancer, as well as clarifying the basic biological processes that guide formation of the ovary.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $803,379.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Reproduction

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

endocrine factors | gonadal development | oestrogen | oestrogen action | ovarian function | ovary | sex reversal | sexual differentiation | testis development

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