Function and inhibition of Plasmepsin V in targeting malaria virulence proteins into human erythrocytes

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010326

Funding Status
Closed

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Funded Activity Summary

Malaria parasites dramatically renovate infected erythrocytes to survive and evade the host immune system by delivering hundreds of exported parasite proteins into the cell. The parasite protease Plasmepsin V is essential for protein export. We aim to develop potent inhibitors of this protease in the hope of blocking its function and killing the parasite. We also aim to discover the components of the trafficking pathway after cleavage by Plasmepsin V that sorts virulence proteins to the host cell.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: Project Grants

Funding Amount: $407,845.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

host/pathogen interaction | inhibitor design | malaria | parasitic disease | parasitic infection | protein complexes | protein trafficking | virulence

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