Prevention of beta cell destruction in type 1 diabetes by immunotherapy using parasite-derived molecules.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010197

Funding Status
Closed

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Funded Activity Summary

To prevent type 1 diabetes, compounds that avert the autoimmune destruction of beta cells are needed. We are exploiting the potential of ñworm therapyî by mimicking the beneficial immune effects of parasite worm infection. We have identified the molecules that the parasite uses to influence host immune responses. We have demonstrated that these novel immune-modulatory worm molecules prevent diabetes in a mouse model. This offers great potential for the development of therapeutic interventions.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $518,443.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene and Molecular Therapy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antioxidant | autoimmune disease | diabetes | helminth infection | infectious diseases | inflammatory diseases | parasitology | protease

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