Molecular mechanisms of inherited hypocholesterolaemias: impact of APOB and MTTP mutations on lipoprotein assembly and secretion

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010133

Funding Status
Closed

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Funded Activity Summary

Inherited low cholesterol levels can be caused by mutations in either of two genes: APOB and MTTP. These genes encode proteins that are critical for the assembly of fat particles in the body. We plan to use cell lines to study how single amino acid changes out of the 4500 in ApoB and the 900 in the MTTP protein affect protein production, binding with other proteins, and fat particle assembly.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $200,213.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

lipid disorders | lipoprotein metabolism | molecular mechanisms | mutation analysis

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