The role of brain inflammation in leptin resistance

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010128

Funding Status
Closed

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Funded Activity Summary

Melanocortin neurons control body weight and are regulated by leptin. In obesity leptin cannot regulate the melanocortin system. We will test if leptin action on melanocortin neurons is limited by increased expression of suppressor of cytokine signalling 3 (SOCS3) in obese mice. As an alternative we will test if there are changes in the blood brain barrier, or an increased density of support and immune cells around melanocortin neurons of obese mice that might restrict inputs to these neurons.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $730,123.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

diabetes | diet | neuropeptide Y (NPY) | obesity | overweight/obesity

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