Protecting fatty livers from hepatic ischemia-reperfusion injury in liver surgery and transplantation

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010082

Funding Status
Closed

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Funded Activity Summary

About one third of the population have a fatty liver, and this greatly increases risks of liver failure after liver surgery or when fatty donor livers are used for transplantation (such organs are currently disposed of). The disease process is called ischemia-reperfusion injury (IRI). The investigators have recently shown that both fibrates and statins provide partial protection against IRI in fatty livers. This research is directed at establish the protective mechanisms, and whether combination drugs are more effective.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: Project Grants

Funding Amount: $624,960.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gastroenterology and Hepatology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cytokines | fatty liver disease | ischaemia/reperfusion | liver failure | liver injury | liver microcirculation | liver transplantation | surgical risk

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