The cardiomyocyte mineralocorticoid receptor plays a critical role in cardiac disease.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1010034

Funding Status
Closed

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Funded Activity Summary

Drugs that block the mineralocorticoid receptor (MR), which responds to adrenal hormones, protect against heart disease and hypertension. We have shown that this effect is in part due to MR blockade in heart muscle cells. This novel finding is being explored further to understand the precise role of the MR in heart muscle cells in normal physiology and in disease. An understanding of the role of the MR in different tissues will enable development of tissue specific treatments for heart disease.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $613,477.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cardiac fibrosis | cardiac hypertrophy | cardiovascular disease | heart failure | hypertension | mineralocorticoid receptor | remodelling | vascular remodelling

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