Investigating Hippo signalling as a novel cause of muscle disease, and as a target for new interventions to combat frailty

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1009995

Funding Status
Closed

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Funded Activity Summary

We will explore the role of the Hippo signaling pathway in muscle development, repair and remodelling. We propose that this little-known pathway which affects organ development, is key for maintaining healthy muscles, and is affected in muscle wasting. Using gene therapy tools to alter this pathway in models of disease, we intend to clarify the role of Hippo signaling in muscle, and establish whether the pathway can be manipulated to treat physical frailty caused by muscle wasting.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: Project Grants

Funding Amount: $460,509.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cell Physiology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ageing | cachexia | frailty | gene therapy | mouse models | muscle development | muscle disease | muscle wasting | muscular dystrophy | wasting syndromes

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