Site-specific integration of functional genomic loci: Applications in gene therapy

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1009989

Funding Status
Closed

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Funded Activity Summary

Gene therapy strategies have traditionally focused on the delivery of therapeutic genes by viral vectors. Mindful of the limitations and potential problems of viral gene delivery, non-specific viral integration and limited transgene expression, this investigation will explore the delivery and site-specific integration of large genomic fragments into human stem cells. It is anticipated this approach will avoid some of the problems associated with poor gene expression and insertional oncogenesis.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2012

Funding Scheme: NHMRC Project Grants

Funding Amount: $442,664.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gene and Molecular Therapy

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

erythropoiesis | gene delivery | gene targeting | gene therapy | mouse models | thalassaemia

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