Defining the role of plasminogen activation in group A streptococcal invasive disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1009369

Funding Status
Closed

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Funded Activity Summary

The "flesh-eating" bacteria group A streptococcus (GAS) causes life threatening invasive diseases such as necrotizing fasciitis and toxic shock syndrome (>600,000 cases and 163,000 deaths per year). For some types of GAS, plasminogen binding is essential for virulence.The aim of this work is to determine the extent to which plasminogen binding contributes to disease caused by highly virulent GAS. These studies will allow the development of new therapeutics and treatments.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2016

Funding Scheme: Career Development Fellowships

Funding Amount: $425,763.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Microbiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

bacterial pathogenicity | group A streptococcal disease | host/pathogen interaction | infectious diseases | innate immunity | necrotising fasciitis | plasminogen | streptococcal invasive diseases | streptococcus

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