Airway inflammation in allergic aspergillosis: characterisation, immunologic mechanisms and treatment.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/100932

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Aspergillus fumigatus is a fungus that commonly occurs in our community. In some people with asthma, this fungus causes the asthma to become severe and chronic. It may also be associated with a severe form of lung destruction called bronchiectasis. There is little known about the chemicals produced by the body which contribute to inflammation in this condition. Similarly, it is not known why only some people with asthma develop an allergic disease to this fungus. In this project we will examine 2 important inflammation chemicals (called cytokines) to examine what their role is in aspergillus associated allergy. We will also examine 2 genetic markers to establish whether these predispose to people developing allergy to aspergillus. The treatment of aspergillus lung disease is also problematic. In this project we will examine whether a new medication called itraconazole is effective in removing this fungus from the airway and improving asthma.

Funded Activity Details

Start Date: 01-01-2000

End Date: 01-01-2002

Funding Scheme: NHMRC Project Grants

Funding Amount: $242,562.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Respiratory Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Airway inflammation | Allergic aspergillosis | Allergy | Aspergillus | Asthma | Eosinophil | Eosinophils and neutrophils | Inflammation | Therapy

Related Links