Telomere structural abnormalities in cells using Alternative Lengthening of Telomeres

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1009231

Funding Status
Closed

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Funded Activity Summary

The continuing growth of cancers depends on their cells being able to prevent shortening of chromosome ends (telomeres). Some cancers, including very aggressive brain and connective tissue tumours, achieve this via the Alternative Lengthening of Telomeres (ALT) process. We have evidence that the telomere structure of normal cells prevents ALT. Here we will examine how the telomere structure of ALT-positive cancer cells is changed, and whether reversing these changes inhibits ALT.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: Project Grants

Funding Amount: $522,122.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

DNA replication | DNA structure | cancer cell biology | cancer research | cell proliferation | immortalisation | molecular basis of disease | recombination | telomeres

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