Mechanisms of PKCepsilon-dependent regulation of beta-cell lipid metabolism and insulin secretion

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1009189

Funding Status
Closed

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Funded Activity Summary

Lipid loading of the insulin-producing beta cells of the pancreas contributes to the onset of Type 2 diabetes, but the mechanisms are poorly understood. We have recently established that inhibiting the enzyme PKCe helps restore insulin secretion. By better defining the cellular role of PKCe we will clarify how insulin secretion is disrupted by fatty acids and cholesterol.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $555,892.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

fatty acid metabolism | insulin secretion | lipotoxicity | pancreatic beta cell | protein kinase C (PKC) | type 2 diabetes mellitus (non-insulin dependent diabetes mellitus)

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