Susceptibility of the basal layer of human epidermis to UVA oxidative damage due to pheomelanin and suboptimal DNA repair

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1009021

Funding Status
Closed

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Funded Activity Summary

Australia has the highest incidence of skin cancer in the world. It is important to understand how sunlight causes skin cancer and the wavelengths involved in order to devise effective preventative and therapeutic strategies. Our proposal is that the cells in the skin that give rise to the most common forms of skin cancer, squamous cell carcinoma and basal cell carcinoma, are particularly vulnerable to UVA. We aim to study why this is the case and whether this vulnerability can be prevented.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $559,354.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Solid Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

keratinocytes | melanocyte | melanoma | skin cancer | solar keratosis | squamous cell carcinoma | sun exposure | sun protection | sunlight | ultraviolet (UV) radiation

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