Characterisation of conserved Sox18-dependent genes in lymphatic vascular development

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1008586

Funding Status
Closed

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Funded Activity Summary

Lymphatic vessels are important in a number of diseases including lymphoedema and cancer. There is a significant gap in our basic understanding of how lymphatic vessels form. We have identified a series of genes that are regulated downstream of the lymphatic master gene Sox18 in mouse lymphatic vessels. This study aims to characterise these genes using complementary model systems. The genes and pathways identified will represent potential therapeutic targets in a number of disease contexts.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $401,355.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Developmental Genetics (incl. Sex Determination)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

SOX genes | cancer metastasis | lymphatic disease | lymphatics | lymphoedema | vascular biology | vascular development | zebrafish

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