The role of BAFF, its receptor TACI and Toll-like receptors in Autoimmunity and Tolerance.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1008520

Funding Status
Closed

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Funded Activity Summary

There are 2 types of immune cells, innate cells reacting broadly against microbial elements, and adaptive cells educated to remember pathogens and provide improved immune responses. Most treatments against lupus target the adaptive cells with mixed success. We have discovered a new mechanism driving lupus at the level of innate immunity. This proposal will identify molecular players driving this unappreciated form of lupus and validate new therapeutic targets.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $486,824.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Innate Immunity

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Toll-like receptors | apoptosis | autoantibodies | autoimmunity | cancer immunology | immunodeficiency | signalling | type I interferon

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