Regulation of expression of microRNAs involved in EMT

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1008440

Funding Status
Closed

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Funded Activity Summary

The majority of deaths from cancer are due to metastasis, which involves cancer cells becoming invasive and migratory. We aim to understand the molecular mechanisms that control this process, which may lead to identification of molecules that are potentially useful for diagnosing and treating cancer metastasis. We will investigate how TGF� regulates the expression of ZEB proteins, how the ZEB proteins function to repress key microRNAs, and what other genes are targeted by the ZEBs.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $559,354.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Biochemistry and Cell Biology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer biology | chromatin structure | epithelial-mesenchymal transition (EMT) | gene expression | gene regulation | microrna | transcription

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