Cellular effects of glucocerebrosidase (GBA) mutations in Lewy body diseases

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1008307

Funding Status
Closed

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Funded Activity Summary

Approximately 1 in 100 people are carriers of mutations in the glucocerebrosidase (GBA) gene and are at considerably greater risk of diseases characterised clinically by parkinsonism and by the presence of Lewy body-related pathology. This study will provide tissue-based evidence of the cellular lipid and protein changes relating to Lewy body formation in patients with GBA mutations, providing the information necessary to identify the pathways and mechanisms involved.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $524,820.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Neurology and Neuromuscular Diseases

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Lewy body | Parkinson disease | alpha-synuclein | dementia with Lewy bodies | gene mutations | lipid disorders

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