Ion channels underlying inflammatory and post-inflammatory visceral mechanical hypersensitivity

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1008100

Funding Status
Closed

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Funded Activity Summary

Inflammation causes tissue damage that triggers ion channels within sensory nerve fibres to produce greater signals in response to mechanical events, causing acute pain. In chronic pain, although the inflamed tissue has healed, sensory nerve fibres fail to "reset" back to normal. Often chronic pain is more severe than acute pain. This project will identify which ion channels are responsible for signalling acute and chronic visceral pain, explaining why sensory nerve fibres fail to reset.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $453,439.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Sensory Systems

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

gastrointestinal symptoms | inflammation | inflammatory bowel disease (IBD) | ion channels | irritable bowel syndrome (IBS) | pain | pain mechanisms | sensory function | sensory neurons | visceral afferents

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