Insulin-like growth factor binding protein-2 is a crucial activator of aggressive behaviour in cancer cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1008062

Funding Status
Closed

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Funded Activity Summary

The insulin-like growth factor (IGF) system, required for normal development and adult life, is often altered in many diseases including cancer. Key regulators of the IGF system are the IGF binding protein (IGFBP) of which IGFBP-2 is the 2nd most abundant. IGFBP-2 may enhance or inhibit the IGFs, but the mechanisms are not clear. This proposal aims to dissect IGFBP-2 action with the ultimate goal to provide knowledge for the development of targeted therapeutic modulators of IGFBP-2 activity.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $612,885.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

endocrinology | gene transcription | insulin-like growth factor binding protein (IGFBP) | insulin-like growth factors (IGF) | integrins | neuroblastoma | peptides | signalling pathways | therapeutic antibodies | therapeutic target

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