Upregulation of dyskerin augments telomerase enzyme activity in haematopoietic cells

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1007911

Funding Status
Closed

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Funded Activity Summary

The replication of cancer cells is unrestricted - they are immortal. Activation of the enzyme telomerase promotes immortalisation in 90% of human cancers. Conversely, telomerase deficiency causes life threatening blood disorders. We will investigate how one of the protein components of telomerase regulates enzyme activity in normal and leukaemic blood cells. The results will be valuable in the pursuit of new approaches to halting cancer cell replication and treating severe blood disorders.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $372,049.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Haematological Tumours

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer biology | cancer cell biology | cell proliferation | erythroleukemia | haematological disorders | myeloid | myelopoiesis | telomerase | telomeres

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