The impact of granzyme B on cytotoxic T cell migration through tissue

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1007830

Funding Status
Closed

Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the .

Funded Activity Summary

Cytotoxic T cells (CTL) are white blood cells that move in an orchestrated way into body tissues to target, and destroy, virus-infected or cancer cells. Destruction of these abnormal cells is achieved when they ingest cytotoxic enzymes (proteases) released by CTL. We propose that one of these cytotoxins, granzyme B, has a dual function, and that it is also involved in helping CTL to efficiently move towards the target cells by clearing a path through the local tissue structure.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $605,963.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

abdominal aortic aneurysm | arthritis | cell migration | cell motility | cell-mediated immunity | cytotoxic T lymphocytes (CTL) | extracellular matrix | granzyme | tumour immunology | viral immunology

Related Links