Role of tissue ferritin as a proinflammatory mediator of hepatic stellate cell activation in hepatic iron overload.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1007532

Funding Status
Closed

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Funded Activity Summary

The hepatic stellate cell is responsible for liver scarring (fibrosis) in chronic liver diseases such as the iron overload condition Haemochromatosis. Our research has identified a role for tissue-derived ferritin as a proinflammatory cytokine in hepatic stellate cell biology. This proposal will examine the mechanisms associated with ferritin's proinflammatory action and assess its role in the fibrosis which occurs in Haemochromatosis.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $574,890.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Gastroenterology and Hepatology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ferritin | haemochromatosis | hepatic fibrosis | hepatic stellate cells | inflammation | inflammatory cytokines | liver cirrhosis | liver disease

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