An essential role for skeletal muscle FoxO1 in protecting against obesity-induced insulin resistance

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1007465

Funding Status
Closed

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Funded Activity Summary

Skeletal muscle is the largest organ in the human body and accounts for approximately 80% of glucose disposal after a meal. We have identified a transcription factor, namely FoxO1, that appears protect against obesity-induced insulin resistance by promoting energy consumption. This project will examine whether skeletal muscle specific activation of FoxO1 is a possible therapeutic target for the treatment of obesity-induced insulin resistance.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: Project Grants

Funding Amount: $593,888.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Physiology not elsewhere classified

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

fat oxidation | insulin resistance | muscle metabolism | obesity | skeletal muscle | transcription factor

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