Investigating the Interaction of Precursor Inner Membrane Proteins with Translocase Components

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1006628

Funding Status
Closed

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Funded Activity Summary

Proteins are synthesised on ribosomes located in the cellular plasm, and then moved to their site of action by specialised transport systems. Import of proteins to the mitochondria involves translocase pores, which come equipped with receptors and chaperones. We are investigating the targeting and transfer of newly synthesised proteins of the MCF carrier family from the ribosomal machinery to the inner mitochondrial membrane, focusing on interaction with chaperones in the intermembrane space.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: Project Grants

Funding Amount: $585,274.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Structural Biology (incl. Macromolecular Modelling)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

deafness | dystonia | membrane protein | mitochondria | mitochondrial function | protein folding | protein targeting | sensory neuropathy | structural biology

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