Regulation of innate immunity and tumour progression by activating transcription factor 3

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1006588

Funding Status
Closed

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Funded Activity Summary

Toll-like receptors (TLRs) play an essential role in innate immune responses and are involved in initiating tumourigenesis via inflammatory pathways. We have shown that the transcription factor ATF3 is a negative regulator of TLR signalling. We will study how modulation of the activity of ATF3 affects the inflammatory response and tumour progression. This will provide a molecular basis on which to design therapeutic reagents for the treatment of cancer.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $473,469.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cancer Cell Biology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer | cytokine network | cytokine signalling | inflammatory mediators | innate immunity | molecular mechanisms | mouse models | tumour | tumour progression

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