The role and underlying mechanisms of constitutional epigenetic silencing in cancer predisposition

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1006498

Funding Status
Closed

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Funded Activity Summary

Familial and young onset bowel and uterine cancer are usually caused by the inheritance of spelling mistakes in the genetic code within a set of cancer-protection genes. Recently, some patients were identified with their gene switched off by paralysing chemicals instead. This study aims to identify additional cancer cases with gene paralysis, determine if this arises in the presence or absence of a genetic change in front of the gene, and how gene paralysis is transmitted to the next generation.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: Career Development Fellowships

Funding Amount: $218,617.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Epigenetics (incl. Genome Methylation and Epigenomics)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

cancer genetics | cancer predisposition | cancer prevention | colorectal cancer | epigenetics | inheritance | mechanism of action | molecular basis of disease

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