Development of a specific activin antagonist for therapeutic applications

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1006488

Funding Status
Closed

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Funded Activity Summary

Activin is a key regulator of homeostasis in several organs and tissues, including ovaries, testes, liver and skin, and alterations in activin�s activity can result in fibrosis, cachexia and cancer. In this grant we propose to develop a specific activin antagonist by modifying the activin A propeptide. This novel reagent could be used to promote liver growth in severe hepatic disease and prevent fibrosis in numerous tissues.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $504,287.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

activin | antagonists | cachexia | fibrosis | follicle-stimulating hormone (FSH) | gonadal malignancy | homeostasis | structure-function | transforming growth factor beta (TGF-beta)

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