Ryanodine receptor inhibitors as therapy for Ca2+ store overload induced arrhythmias

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1005974

Funding Status
Closed

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Funded Activity Summary

This study investigates a new therapeutic action recently discovered for flecainide, an antiarrhythmic agent that we find to completely prevent and inherited form of stress-induced arrhythmias called CPVT. The findings will provide the first detailed mechanistic understanding of an antiarrhythmic drug, findings that will also give a new direction for drug design to control common arrhythmias such as occur in diseases such as coronary artery disease.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $555,892.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical and Health Sciences

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

calcium imaging | calcium release | cardiac arrhythmia | cardiac disease | cardiac electrophysiology | cardiac ischaemia | drugs problems

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