TNF traffic and secretion in astrocytes and microglial cells: unveilling new targets for ischemic stroke

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1005964

Funding Status
Closed

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Funded Activity Summary

Neurodegenerative disorders share a similar pathway to disastrous neurotoxicity, which occurs through the release of cytokines such as tumour necrosis factor-a (TNF) from glial cells. TNF controls inflammation but its excessive secretion in the brain is highly detrimental. The mechanism of TNF secretion is unknown but strategies aimed at reducing it have therapeutic potential. This grant proposes to study TNF discharge to find new ways to reduce secretion and confer protection in a stroke model.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $585,070.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cellular Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

Alzheimer disease | Golgi | acute stroke | anti-inflammatory | exocytosis | microglia | multiple sclerosis (MS) | trafficking

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