Assessing the role of the N-terminus of the prion protein, emphasising constitutive cleavage, in normal function and pathogenesis, as well as defining the relationship between intensity of surveillance and sporadic CJD incidence.

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1005816

Funding Status
Closed

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Funded Activity Summary

As a neurologist undertaking research into prion diseases over an extended period, I have been able to lead and participate in many projects that have made significant contributions, such as validation of new diagnostic tests for Creutzfeldt-Jakob disease (CJD), assessment of potential therapeutics, provide insights into the normal function of the prion protein and the underlying pathways causing cellular damage and determine the real significance of apparent clusters of sporadic CJD.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2015

Funding Scheme: Practitioner Fellowship

Funding Amount: $387,469.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Central Nervous System

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

age-related | cell membrane | cell signalling | dementia | neurodegenerative disorders | neuronal degeneration | prion diseases | transmission

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