beta-Adrenergic activation: a double-edged sword on cardiac angiogenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1005329

Funding Status
Closed

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Funded Activity Summary

We will test our hypothesis that activation of beta-adrenergic receptors (b-AR) regulates significantly on growth of blood vessels in the heart. While initialy promoting vessel growth, prolonged stimulation of b-AR, a situation seen with diseased hearts, suppresses vessel growth thereby promoting disease progression. This hypothesis is strongly supported by our recent experimental findings and would have important clinical implication on the treatment of patients with heart disease.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $365,126.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Cardiology (incl. Cardiovascular Diseases)

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

adrenoceptors | angiogenesis | angiogenic-dependent diseases | cardiomyopathy | epigenetics | heart failure | hypertrophy | neovascularisation | vascular endothelial growth factor (VEGF)

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