ATR-X syndrome: Role of ATRX in testicular growth and spermatogenesis

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1004992

Funding Status
Closed

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Funded Activity Summary

Infertility is surprisingly common and affects 1 in 20 Australian men. Testosterone and its receptor, the androgen receptor, are well known to be essential for spermatogenesis and fertility. We have identified an important regulator protein (ATRX) of androgen receptor activity and show that loss of function of ATRX in testes of mice leads to spermatogenesis defects. Identifying the molecular action of ATRX will lead to a better understanding of the underlying causes of infertility in men.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2013

Funding Scheme: NHMRC Project Grants

Funding Amount: $650,881.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Endocrinology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

ATRX syndrome - alpha thalassemia-mental retardation of the X | gonadal dysgenesis | male infertility | male reproduction | pseudohermaphrotidism | reproductive biology | spermatogenesis | testis | testis development

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