Hepatitis B Virus Covalently Closed Circular DNA

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1004847

Funding Status
Closed

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Funded Activity Summary

Worldwide >360 million people have chronic hepatitis B virus (HBV) infection that imparts a 25% lifetime risk of death due to serious liver disease. Current therapies for chronic HBV reduce levels of virus replication but fail to target the stable, nuclear episome, covalently closed circular DNA (cccDNA). The current study will determine what is required to eliminate cccDNA and how current therapies for chronic HBV infection should be modified to achieve this aim.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: Project Grants

Funding Amount: $302,981.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Medical Virology

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

antiviral therapy | cell proliferation | duck hepatitis B virus | hepatitis B infection | hepatitis B virus | hepatocytes | liver disease | paracetamol toxicity | viral persistence | viral replication

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