Regulation of the Nedd4 family of ubiquitin ligases by adaptor and accessory proteins in normal physiology and in disease

Funding Activity

Website
http://purl.org/au-research/grants/nhmrc/1004572

Funding Status
Closed

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Funded Activity Summary

In part this proposal is to understand how the body controls iron uptake through iron transporters DMT1 and Nramp1. We will study the regulation of these transporters by proteins called Ndfip1, Ndfip2 and arrestins. We will also study the functions of these proteins in controlling ubiquitination, a fundamental process required for cellular homeostasis. The results from this study may ultimately contribute to the development of novel therapies for certain human diseases.

Funded Activity Details

Start Date: 01-01-2011

End Date: 01-01-2014

Funding Scheme: NHMRC Project Grants

Funding Amount: $609,424.00

Funder: National Health and Medical Research Council

Research Topics

ANZSRC Field of Research (FoR)

Protein Trafficking

ANZSRC Socio-Economic Objective (SEO)

There are no SEO codes available for this funding activity

Other Keywords

disease mechanisms | haematology | inflammation | iron deficiency | iron transport | molecular basis of disease | mouse models | protein-protein interaction | ubiquitin-mediated proteolysis | ubiquitination

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